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he FTSE100 is set to fall nearly 2% when it opens on Thursday morning, according to futures trade, with the Wall Street markets also heading for a hefty loss.

Mike Kelly, head of global multi-asset at PineBridge Investments in the US, said it was a sign to “get the heck out” of US stocks. “It’s all about selling longer duration assets,” he said, “so we are underexposed to US equities.”

In its latest policy update on Wednesday, the US Federal Reserve chairman, Jerome Powell, indicated the central bank was likely to raise interest rates in March, and reaffirmed plans to end its Covid-emergency bond purchases that month before launching a significant reduction in its asset holdings.

But in the follow-up press conference, Powell warned that inflation – which has hit levels not seen for decades – remains above the Fed’s long-run goal and supply chain issues may be more persistent than previously thought.

“There was a marked shift in terms of a relatively dovish statement and then a relatively hawkish press conference,” said David Chao, global market strategist, Asia Pacific at Invesco.

“Powell is not committing to the size or the frequency of rate hikes and also the timing of the balance sheet reduction. I think that buys him a bit of wriggle room as to how quickly and with what velocity he wants to normalise monetary policy in the US.”

Chao said, however, that any further rise in inflation in the US, which is now running at 7%, could lead to “a more aggressive monetary policy tightening” meaning more US rate hikes.

A tougher stance by the Fed is expected to see other central banks drop into line or continue to increase rates, such as in the Bank of England’s case, which increased borrowing costs in December to crub rising consumer prices. The central bank in South Korea has already hiked rates three times in six months

“With the somewhat hawkish signals by the Fed … there may be greater pressure for central banks to act on curbing inflationary pressures as well,” wrote Yeap Jun Rong, market strategist at IG. Earlier this week, Singapore’s central bank surprised markets by tightening its monetary policy settings in its first out-of-cycle move in seven years.

The US dollar rose on Thursday on the back of higher US bond yields, lifting the dollar index – which measures the greenback against major peers – to 96.604, near five-week highs. The pound slipped to $1.343.

The global benchmark Brent crude fell 0.64% on profit-taking to $89.38 per barrel.